DRUG DISCOVERY

A behavioural study assessing spatial memory deficits in the APP/PS1 double transgenic mouse model of Alzheimer's disease using the Morris water maze – Stephen Edwards, The University of Queensland, p10
Alternative splicing of spca1 in breast cancer cell lines – Mariam Rizk, University of Queensland, p17
2’-methoxy-6-methylflavone: a novel allosteric activator of α4β1/2/3 GABAA receptors – Nasiara Karim, The University of Sydney, p23
3-oh-2’-methoxy-6-methylflavone: an allosteric modulator of synaptic while activator of extrasynaptic gabaa receptors - Nasiara Karim, The University of Sydney, p24.
Transcriptional Up-Regulation Of Human Udp Glucuronosyltransferase (Ugt) 2b15 And 2b17 By Dihydrotestosterone And Its Metabolites In Breast Cancer Mcf-7 Cells - Dong Gui Hu, Flinders University, p29
IP3R-binding protein released with IP3 (irbit) in breast cancer cell lines – Aisyah Jahidin, The University of Queensland, p31
Investigate the species difference caffeine effect on TRPA1 ion channel – Liuqiong Gu, University of Melbourne, p38
Assessment of plasma membrane calcium atpase 1 sirna-mediated inhibition in MDA-MB-231 breast cancer cells – Merril Curry, The University of Queensland, p54
Stimulus-bias at the relaxin family peptide receptor 3 (RXFP3) – Martina Kocan, Monash University, p90
Autocrine annexin-1 activates formyl peptide receptors to increase breast tumour cell proliferation in response to serum, estradiol and epidermal growth factor – Thippadey Khau, University of Melbourne, p93

Moonlighting enzymes: can kinases also contain guanylate cyclase activity? – Lubna Freihat, Monash, p98
Long-lasting effects of early-life stress on GABA-A receptors – Tina Hinton, The University of Sydney, p102
Predicting 5-HT1A receptor affinity of 1-adrenoceptor ligands – Timothy Nicholas, UNSW, p128
The role of PNU-120596, a selective positive allosteric modulator of the α7 nicotinic acetylcholine receptor in inflammation – Aileen Wu, University of Sydney, p134
Pathway-dependent allosteric modulation of the calcium sensing receptor – Anna Davey, Monash University, p136
The effects of abt-089 and analogues on stoichiometric combinations of RAT 4β2 nAChR - Taima Qudah, Sydney University, p151
Affinity and selectivity of diquinoline compounds at adrenoceptors and 5-HT_1A receptor – Junli Chen, University of New South Wales, p152
Modulation of ligand binding to the 1b adrenoceptor: a potential role for the second extracellular loop – Adrian Campbell, University of New South Wales, p163
Structure-function studies of the human extracellular calcium-sensing receptor – Chongkai Wen, Monash Institute of Pharmaceutical Sciences, p178
Novel allosteric modultors and hybrid orthosteric/allosteric ligands of the adenosine a1 receptor – Emilia Savage, Monash University, p181
A putative modulator of the neurotrophin receptor P75NTR regulates peripheral myelination - Yong Zhou Lim, University of Melbourne, p185
Interaction with caveolin-1 modulates differential g protein coupling of mouse beta3-adrenoceptor isoforms – Bronwyn Evans, Monash Institute of Pharmaceutical Sciences, p186
Naringin and tertiapin-q share a binding site on girk channels – Elena Pera, University of Sydney, p11
Deglycosylation of the osmoreceptor trpv4 increases its basal activity  and permeability to the large cationic dye yo-pro 1 – Fe Abogadie, University of Melbourne, p52
Ethanol extracts of saw palmetto contain the indirectly acting sympathomimetic tyramine – Thiam Chua, Monash University, p64

Cysteine residues in the TRPV1 pore loop are critical determinants of channel calcium and Yo-Pro permeability – Marianna Volpert, University of Melbourne, p137
Revealing important roles for n-glycosylation in pore dilation and sustained elevation of intracellular calcium of the trpv1 receptor – Nik Veldhuis, University of Melbourne, p139
Valproate and the promiscuous delta-containing gabaa receptors – Divya Iyer, University of Sydney, p153
The serotonin 5-HT4 receptor splice variants interacts with specific PDZ domain proteins veli 1-3/LIN7A, B, C homologues: mechanisms in receptor targeting – Kenneth Chinkwo, Monash University, p169
Mutations in TRPV4 cause an inherited arthropathy of hands and feet – Yuan Yuan, University of Melbourne, p172
Wound healing efficacy of seabuckthorn leaf aqueous extract in diabetic rats – Nitin Kumar Upadhyay, University of Delhi, p174
Drug transporters in human mammary epithelial cells - Lisa B.G. Tee, Curtin University, p195
Investigating the role of the low density lipoprotein class A (LDLA) module in mediating activation of the relaxin family peptide receptor (RXFP) 1 and RXFP2 - Roy Chze Khai Kong, Howard Florey Institute, p75
Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue – Virginia Ip, University of Auckland, p88
Growth factor-mediated changes in purinergic receptor signaling in breast cancer cells – Felicity Davis, The University of Queensland, p9 

DRUG DISPOSITION

Hepatic Drug Disposition in Liver Disease: Liver histopathology and hepatic drug transporter activity as determinants of drug disposition in liver diseases – Peng Li, The University of Queensland, p7

UDP-glucuronosyltransferase 2B7 (UGT2B7) Utilises Both UDP-Glucuronic Acid and UDP-Glucose as Co-factors in the Metabolism of Morphine – Nuy Chau, Flinders University, p94
Computational modeling and structure-activity relationships of cytochrome P450 1A1: enhanced activation of the chemotherapeutic prodrug dacarbazine – Benjamin Lewis, Flinders University, p188
Comparison of drug binding to human serum albumin and liver fatty acid binding protein; potential implications for intra and inter cellular hepatic transport – Andrew Rowland, Flinders University, p37
Prediction of paclitaxel clearance from in vitro kinetic data – Tahlia Heath, University of South Australia, p21 

GASTRO-UROGENITAL

Spontaneous activity in isolated bladder strips from the streptozotocin-induced diabetic rat: effct of cholinergic modulation and the mucosa – Donna Sellers, Bond University, p12
Investigating the atheroprotective effect of testosterone: role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model – Donna Sellers, Bond University, p13
The effect of ovariectomy and dietary phytoestrogen on relaxant responses to adenosine receptor analogues in the rat isolated bladder – Roselyn Rose'Meyer, Griffith University, p39
NKA modulation of urothelial and detrusor responses to ATP and carbachol – Natasha Hausman, Bond University, p87
Relaxant effects of methanandamide unmasked by indomethacin in the mouse uterus – Karen Kerr, University of Newcastle, p104
Characterisation of the muscarinic receptor subtype regulating urothelial spontaneous contractile activity – Christian Moro, Bond University, p105
Short term cafeteria diet increases serotonin availability in the rat ileum – Rebecca Bertrand, University of New South Wales, p108
The influence of the mucosa on contractile responses of the internal anal sphincter (IAS) – Russ Chess-Williams, Bond University, p127
Amiloride reduces 5-HT release from EC cells of guinea pig intestine – Kate Polglaze, University of New South Wales, p131
Age related changes in the contractile response of the mouse prostate gland – Carl White, Monash Institute of Pharmaceutical Science, Monash University, p135
Differential expression of oestrogen and progesterone receptors in the colon of females with slow transit constipation – Lu Liu, University of New South Wales, p142

Characterisation of inflammatory phenotype in human colitis explant model – Benjamin Harvey, The University of Adelaide, p148
Identifying novel urinary biomarkers – towards a new therapeutic target in overactive bladder (OAB) disease – Orla Teahan, UNSW, p149

INFLAMMATION/RESPIRATORY

Serum-induced chemo- attractant and kinetic responses of MDA-MB-231 breast tumour cells are prevented by dexamethasone, but uninfluenced by formyl peptide receptor (FPR) ligands – Ebony Fietz, University of Melbourne, p22
Morphine- and LPS-induced cellular proinflammatory cytokine production in mice: comparison of three mouse strains – Liang Liu, University of Adelaide, p42
Suppression of inflammation by opioids and bisphosphonates in arthritis - Jignya H Patel, University of New South Wales, p50
Deletion of the interferon a receptor1 (IFNAR1) subunit of the type I interferon receptor confers protection to neuronal tissue following traumatic brain injury – Ila Karve, University of Melbourne, p58

Expression and function of FcγRIIa in mast cells and the lung: a role in asthma? – Patrick Heng, University of Melbourne, p68
Function and expression of novel MS4A members in atopic asthma - Li Eon Kuek, University of Melbourne, p69
Glutathione peroxidase-1 (GPX-1) reduces influenza a virus-induced lung inflammation – Selcuk Yatmaz, The University of Melbourne, p91
Implications of interferon dependant activation of JAK-STAT pathway in neuro-inflammation – Myles Minter, University of Melbourne, p115

3, 4-methylenedioxymethamphetamine (MDMA) – induced hyperthermia is attenuated by administration of interleukin-1 (IL-1) receptor antagonist (IL-1RA) in rats – Jake Gordon, University of Adelaide, p124
Recombinant granulocyte/macrophage colony-stimulating factor (GM-CSF) fails to restore macrophage function, and surfactant proteins (SP) suppress host defences, in pulmonary alveolar proteinosis (PAP) – Matt Radojcic, University of Melbourne, p132
Transforming growth factor β (TGFβ) induces glucocorticoid-resistance in human airway epithelia by reducing glucocorticoid receptor nuclear localisation – Saad Salem, The Univesity of Melbourne, p146
Influence of influenza infection on sensory nerve function in mouse airways – Samuel Taylor, University of Western Australia,p62
IL-4, IL-13 and TNF TNFα Inhibit GRE activation and synergise to down-regulate GRα levels in human bronchial epithelial cells – Christine Keenan, University of Melbourne, p121
Airway reactivity to both constrictors and dilators is altered in vitro in a sheep model of chronic allergic airways disease – James Esposito, University of Melbourne, p125

CARDIOVASCULAR

Yeh Siang Lau, University of Malaya, p34
Effect of carpobrotus rossii (‘pigface”) ingestion on blood pressure, body and organ weight, blood lipids, haematological profile and in vitro vascular responses in rats – Dominic Geraghty, University of Tasmania, p36
Resistin can act in the brain to influence cardiovascular regulation – Samin Kosari, RMIT University, p61
TRPC3 channels facilitate KCA-mediated endothelial signaling in rat mesenteric artery – Sevvandi Senadheera, University of New South Wales, p72
Are the cardiac effects of nitroxyl (HNO) preserved in a high glucose setting in neonatal rat cardiomyocytes (NRCM)? – Shreeleka Rao, University of Melbourne, p92
Effects of omega-3 fatty acids and proinflammatory mediators on superoxide generation and nitric oxide synthase (eNOS) expression in quiescent human umbilical vein endothelial cells (HUVECs) – Karina Hamilton, University of the Sunshine Coast, p110
Nitroxyl (HNO) suppresses superoxide generation by nadph-oxidase in the cerebral vasculature – Kate Maxwell, Monash University, p112
Effects of omega-3 fatty acid supplementation on Weibel-Palade body degranulation in human endothelial cells – Corinna Burgin, University of the Sunshine Coast, p122
A reduced capacity to exercise is associated with cardiac remodelling in rats – Marissa Bowden,  Baker IDI Heart and Diabetes Institute, p133
Endothelial cationic amino acid transporter 1 (CAT-1) overexpression protects against diabetes-induced cardiac dysfunction in mice – Makhala Khammy, The University of Melbourne, p140
The effects of serum, ischemia and adenosine receptor activation on erk phosphorylation in a cardiac cell line model – Ruchi Kanojia, Monash University, p157
Contribution of transmembrane domain V amino acids to β_1L-adrenoceptor activity and affinity – Paul Klenowski, Queensland University of Technology, p170
Macrophages in the vascular wall of hypertensive mice are ‘alternatively’ activated and derived from circulating LY6C^HI monocytes – Jeffrey Moore, Monash University, p182
Zoledronic acid increases eNOS expression and improves endothelial function – Oguzhan Yildiz, Gulhane School of Medicine, Ankara, Turkey, p3
Heart rate variability more sensitive than cortisol to exam stress in students – Sara Vafaeiafraz, The University of Sydney, p20
Diet-induced obesity alters vasodilator mechanisms in the rat middle-cerebral artery – Lauren Howitt, UNSW, p86
The sphingosine 1-phosphate mimetic, FTY720, suppresses superoxide generation and elicits nitric oxide-dependent dilatation in the cerebral circulation – Jacqueline Ku, Monash University, p99
Effect of glycated human serum albumin on BKCa-mediated responses in rat and human small arteries - Matthew           Rikard-Bell, UNSW, p120
Correction of abnormal fenestrations in the diabetic liver with 3,3’,5,5’-tetra-t-butyl-biphenyl-4,4’-diol, a novel antioxidant compound – Aisling McMahon, ANZAC Research Institute, p162
Do connexins 37, 40 and 43 play a role in endothelial dysfunction in cremaster arteries from type-2 diabetic rats? – Marshan Youssef, RMIT University, p180
Olfactory receptor systems in the heart – Simon Foster, University of Queensland,p197
Vasorelaxant and anti-aggregatory actions of nitroxyl (HNO) are preserved, yet those to nitric oxide (NO) compromised, in hypercholesterolemic mice – Michelle Bullen, Monash University, p116 
MyD88-dependent signaling following stroke – Catherine Downes, Melbourne University, p126

CLINICAL

The effect of allopurinol on thiopurine metabolite concentrations in patients with inflammatory bowel disease – Tegan Asser, University of South Australia, p28
Local anaesthetic infused at the incision site for post-operative pain management following abdominal surgery – Ray Morris, The Queen Elizabeth Hospital, p33
Drug burden index (DBI) associated with function in older people living in Finland – Danijela Gnjidic, University of Sydney and Royal North Shore Hospital, p45
Development of a population pharmacokinetic (POPPK) model to describe the variability in metformin pharmacokinetics – Shaun Kumar, St Vincent's Hospital, p55
Optimising the management of gout with allopurinol – Diluk Kannangara, St Vincent's Hospital, p57
Multimodal CNS pharmacodynamics with the neurocart using lorazepam as a probe drug – Nur Yasmin Ayub, University of Adelaide, p73
A comparison of suspected paracetamol toxicity in young and old patients at a Sydney hospital over 18 months – Alice Kane, University of Sydney/Royal North Shore Hospital, p101
Presentation of sepsis and gentamicin dosing in young and old hospital inpatients – Claire Johnston, University of Sydney/Royal North Shore Hospital, p109
The impact of frailty on gentamicin pharmacokinetics in septic older inpatients – Claire Johnston, University of Sydney/Royal North Shore Hospital, p113
Development of an LC-MS/MS method suitable for tacrolimus quantification in tissue – Benjamin Noll, The Queen Elizabeth Hospital, p144
Intra-renal cyclosporine concentrations in kidney transplant recipients experiencing rejection or other graft dysfunction – Benedetta Sallustio, The Queen Elizabeth Hospital, p158
The acute effects of naltrexone on the psychomotor effect of alcohol in healthy volunteers – Nur Yasmin Ayub, University of Adelaide, p171
Comparison of one vs two blood samples for determination of tobramycin AUC in children with cystic fibrosis – Ross Norris, Mater Health Services, p190
Blood collection technique for pharmacokinetic studies of doxorubicin in paediatric patients – Michael Lobb, Mater Health Services, p196
Short-term exposure of patients with chronic renal impairment to metformin – Janna Duong, University of New South Wales, p8
Drug burden index (DBI) and mortality in Australian veteran population – Danijela Gnjidic, University of Sydney and Royal North Shore Hospital, p117
Assessment of cytochrome P450 inactivation efficacy as a predictor of pharmacokinetic drug-drug interactions – Kyra Barnes, Flinders University, p25
The assay of melatonin in saliva by high-performance liquid chromatography-tandem mass spectrometry – Sohil Khan, The University of Queensland, p194
Pulmonary fibroblasts from patients with COPD have a senescent secretory phenotype – Lian Wu, University of Auckland, p211
Drug burden index (DBI) and beers criteria: impact on function in older people living in self-care retirement villages – Danijela Gnjidic, University of Sydney and Royal North Shore Hospital, p47
Opioid analgesia, tolerance and withdrawal: contributions of innate immune signalling and sex – Mark Hutchinson, University of Adelaide, p60
Patients’ perceptions of generic medications - Suong N T Ngo, The University of Adelaide, p166

PHARMACOGENOMICS

Mechanistic contribution of toll-like receptors and microglia towards alcohol effects and alcohol-opioid interactions – Yue Wu, University of Adelaide, p18
Counter regulation of morphine and oxycodone analgesia: a TLR4 map kinase mediated phenomenon? – Jacob Thomas, University of Adelaide, p56
Identification of transcription factors regulating UDP-glycosyltransferase 3A1 and 3A2 gene expression – Alex Haines, Flinders University, p95
Microarray analysis of global gene expression as a tool to identify potential drug targets for the treatment of werner syndrome. Studies in a mouse model – Dmitri Svistounov, ANZAC Research Institute,p193

TOXICOLOGY

Transcriptome profiling of acute acrolein pneumotoxicity in mice – Philip Burcham, University of Western Australia, p46
Illicit stimulant use in adelaide monitored by wastewater analysis – Chang Chen, University of Adelaide, p51
Effect of paracetamol toxicity on kupffer cell numbers in perfused livers of young male fischer 344 rats – Alice Kane, University of Sydney/Royal North Shore Hospital,p103
The impact of poloxamer 407 (P407) on the ultrastructure of the liver and evidence for clearance by extensive endothelial and kupffer cell endocytosis – Alessandra Warren, University of Sydney, p192
The expression of NRF2 and CYP2E1 in paracetamol induced hepatoxicity of fisher 344 rats – John Mach, Royal North Shore Hospital, p164
Cytotoxic and apoptosis induction of Malaysian marine endophytic fungi – Siti Alwani Ariffin, Otago University of Wellington, p165
Prior acute acrolein exposure accelerates the onset of pulmonary inflammation in influenza a infected mice – Ferrer Ong, University of Western Australia, p187 
Solving the ‘brown snake paradox’: an in vitro comparison of the activity of snake presynaptic neurotoxins – Carmel Barber, Monash University, p71


EDUCATION

Is non-attendance at lectures indicative of lack of engagement of students with their studies? – Elizabeth Davis, Monash University, p19
Ensuring quality graduates of pharmacology: a survey of Australian students – Lynette Fernandes, University of Western Australia, p129
e-Pharmacology: An on-line resource for medical students – Eva Patak, Monash University, p141
Ensuring quality graduates of pharmacology: an Australian survey of pharmacology teaching – Tina Hinton, The University of Sydney, p143
Assessing student preconceptions and misconceptions of therapeutic pharmacology topics as an engagement and teaching strategy – Joanne Hart, RMIT University, p179

GASTRO-UROGENITAL
Physiological concentrations of iron alter the motility of the guinea pig jejunum – Kej Wang, University of New South Wales, p130