2013 ASCEPT Annual Scientific Meeting

2013 ASCEPT scientific program

2013 Symposia

Symposium 1: Drug Discovery/Neuro SIGs
The long and winding road to discovering drugs for brain and mind disorders
Speaker biographies, please click here

Symposium 2: Pharmacogenomics/Clinical Pharmacology SIGs
Barriers to pharmacogenomic testing being incorporated into clinical practice
Speaker biographies, please click here

Symposium 3: Cardiovascular/Neuro SIGs
Inflammation & immunity: new frontiers for the treatment of cardiovascular & neurological diseases
Speaker biographies, please click here

Symposium 4: Drug Disposition and Response SIG
Addressing the Complexities of Cytochrome P450 metabolism
Speaker biographies, please click here

Symposium 5: Drug Discovery SIG
Drug discovery: a collaborative effort
Speaker biographies, please click here

Symposium 6: Urogenital and Gastrointestinal SIG
Interstitial cells as novel pharmacological targets: advances in gastro-intestinal and urogenital systems
Speaker biographies, please click here

Symposium 7: Education Forum
From pipette to patient to policy – training pharmacologists for the future
Speaker biographies, please click here

Satellite Meeting – Natural Products Research Conference

Thursday 5th December

Venue: The Design Hub, RMIT University (cnr Victoria and Swanston Street, Melbourne)

The focus of the conference will be basic and clinical research, from venoms and plant extracts to recombinant mammalian proteins:

designing new treatments for metabolic disease from natural product leads,
designing new pain-killing drugs from toxins and other natural products,
designing nutriceuticals and
new frontiers in designing therapeutics from natural product leads.

Keynote speakers:

Prof Baldomero Olivera, Distinguished Professor of Biology, University of Utah
Prof Jeffrey White, Director, Office of Cancer Complementary and Alternative Medicine, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institute of Health (U.S.A.)

For further information and to register, please go to:
www.rmit.edu.au/research/institutes/healthinnovations

Download Satellite Meeting flyer

Workshops

ASCEPT Pharmacogenomics workshop – “PGx: new research interests and directions”

Date: Sunday, 1 December 2013
Time: 10.00am-12.00pm (including SIG AGM from 11.30am – 12.00pm)
Venue: RACV City Club, 501 Bourke Street, Melbourne
Cost: Complimentary
Registration: RSVP by COB 22/11/13 to Janet Coller at: janet.coller@adelaide.edu.au

Program:
Chair: Prof Andrew Somogyi

10.00-10.10	Welcome
10.10–10.40	“Inter individual variation in the expression of pharmacogenes is epigenetic control important?”
	Dr Nuala Helsby, School of Medical Sciences, The University of Auckland, Auckland, NZ
10.40–11.00	“NHMRC Best of 10” “Fluoropyrimidine toxicity: A nasty way to die. But can pharmacogenetics help?”
	Dr John Duley, School of Pharmacy, The University of Queensland, QLD, Australia
11.00–11.15	Short presentation TBC*
11.15–11.30	Short presentation TBC*
11.30–12.00	PGx SIG AGM

*Nominations by Honours, Masters and PhD candidates, and ECR are encouraged to fill these presentation times, please submit a title and brief abstract (100 words) to Janet Coller (janet.coller@adelaide.edu.au) by COB 15/11/13 for consideration.

ASCEPT Education Forum workshop – “Ideas Exchange: Engaging the Net generation”

Date: Sunday, 1 December 2013
Time: 2.30pm-4.30pm
Venue: RACV City Club, 501 Bourke Street, Melbourne
Cost: Complimentary
Registration: Register for the workshop via the conference registration page

This workshop is aimed at highlighting ideas and initiatives in teaching that have been introduced to try to better engage students in the learning of pharmacology. The talks will provide a brief overview of these initiatives (the why and how of their introduction) and any changes that might be made if it were to be used again. After each talk there will be time for an exchange of ideas from others who may have developed or used similar teaching activities, or questions from those who might be interested in incorporating it into their teaching.

Using videos in practical teaching – Elizabeth Davis, Monash University
We are using videos to replace face-to face pre-practical talks in an effort to increase student preparedness for and engagement in practical sessions. In addition, we have incorporated “wrap-up” videos to help students in the preparation of their practical reports. In this presentation I’ll discuss the why and how – and present some initial feedback from staff and students.

An iPad/iPhone pharmacology resource – Lynette Fernandes, University of Western Australia
A Pharmacology app and online resource has been developed by Robert Rissmann and colleagues at Leiden University, Netherlands. This app provides an additional resource for students and, according to Prof Simon Maxwell (University of Edinburgh), “it’s the best”.

Using a TBL approach and the 4 S’s to engage 1st yr B.Nursing students in the learning of pharmacodynamics – Janet Coller, University of Adelaide
Effective learning of pharmacodynamics is pivotal to form the basis for understanding pharmacology. Historically, tutorials have consisted of a series of questions (MCQs and SAQs) that the students are expected to attempt prior to attending the face-to-face session and the lecturer then goes through these set questions asking for student participation. My experience with students is that they either don’t attempt the questions beforehand, or are hesitant to be engaged in the face-to-face (F2F) session. This results in the session being more like a traditional lecture than an active “engaged” session. One potential solution to lack of engagement was to use a TBL / 4S (significant, same, specific and simultaneous) approach to the session which will be discussed.

Using Mahara / EPortfolio for engaging students in group work – Nicole Jones, University of New South Wales
We have used Mahara/EPortfolio to get students to engage more with group work throughout a project. Every week, students reflected on different aspects of their project group work (including: their participation, the group’s participation overall, problems and how they were overcome, as well as the content). I will discuss the reasoning behind improving how we look at group work, how we have implemented this and provide some staff/student feedback on the process.

ASCEPT Careers workshop – “Careers spanning academia, industry and government”

Careers spanning academia, industry and government
Co-chairs: Ms Michelle Bullen, PhD student, Monash University; Mr Adrian Campbell, PhD student, UNSW
Convenor: Dr Barbara Kemp-Harper, Monash University

A new career in the Pharmaceutical Industry
Ms Chantelle Gardiner-Mann, Medical Information and Pharmacovigilance Associate, UCB Australia
Opportunities stemming from postgraduate research: Where do I fit in?
Dr Vidya Perera, Postdoctoral Fellow, Novartis/University of Buffalo, USA
Transitioning Careers- How did I wind up here? A journey from Researcher to Government Scientist & Policy Advisor to S&T Policy Think Tank
Dr Margaret Hartley, CEO, Australian Academy of Technological Sciences and Engineering
When I grow up, I want to be….
Dr Shane Patella, Director Pantheon Consulting

ASCEPT Clinical Pharmacology workshop – “Pharmacokinetic models – uses and misuses“

Why should we use pharmacokinetic modelling and how do pharmacokinetic models help us treat patients? Our speakers will discuss strengths and limitations of different approaches to pharmacokinetic data, illustrated by critiques of big and small studies. This workshop is for clinical pharmacology trainees, students and conference attendees with an understanding of basic pharmacokinetics who are regularly exposed to clinical literature.

A century of lessons in and from pharmacokinetics
Prof Evan Begg, University of Otago

Using population pharmacokinetics, what I’ve learnt so far
Dr Dan Wright, School of Pharmacy, University of Otago

Pharmacokinetic analyses and clinical studies
Prof Carl Kirkpatrick, Monash University

Panel Discussion

Invited speakers

Dr Patrick Smith (PharmD)

Chief Scientific Officer, d3 Medicine LLC

d3 Medicine LLC is a global company that provides the biopharmaceutical industry with unique access to a virtual drug development team of globally recognised industry practice leaders with a passion to drive change in areas of unmet medical need. Dr. Smith has more than 15 years of global drug development experience and is considered an authority in anti-infective and antiviral clinical pharmacology. Dr. Smith has broad appreciation for all aspects of drug development, with particular emphasis on innovative translational and quantitative approaches in early phase development to optimize speed and efficient proof of concept delivery Past appointment includes Head of U.S. Clinical Pharmacology for Roche, member of key infectious diseases corporate governance committees defining disease area and portfolio strategy. He holds a Research Associate Professor appointment at the State University of New York at Buffalo and has more than 80 peer reviewed publications in top tier journals.

Dr Craig Rayner (PharmD MBA)

CEO, d3 Medicine LLC

d3 Medicine LLC is a global company that provides the biopharmaceutical industry with unique access to a virtual drug development team of globally recognised industry practice leaders with a passion to drive change in areas of unmet medical need. Dr. Rayner has more than 15 years of drug development experience. His past appointments including Leadership roles in Clinical Pharmacology and Early development (Roche), Clinical development (CSL-Behring), and in Business Development/Licensing as Global Due Diligence Director (Roche). He has extensive experience in early and late development of therapeutics, regulatory interaction experience with all major global health authorities, multiple filings and accountability for numerous Due Diligences, active support of negotiations, deal making and integration activities. He holds an Adjunct Associate Professorship in Pharmaceutical Science, and is broadly published in clinical pharmacology and also infectious diseases.

Dr John Warren

Clinical Scientist, Medicines Assessment Ltd

John began Medicines Assessment Ltd as a pharmaceutical consultancy in 2011. He advises multiple pharmaceutical companies on their clinical development programs, including non-executive director advice to the biotech and pharma industry. John is currently Executive Editor for British J Clinical Pharmacology and member of the Joint Specialty Committee for Clinical Pharmacology of the Royal College of Physicians London.John previously worked for the UK Medicines Healthcare products Regulatory Agency (MHRA) as an Expert Medical Assessor from 1995-2010 evaluating new drug applications for the UK and Europe across the therapeutic spectrum. He was a member of the European Scientific Advice Working Party from 2003-2010 and the European Pharmacokinetic Subgroup of the Efficacy Working Party from 2007-2008. He contributed to the EU Notes for Guidance on Asthma, COPD, ARDS and Bioequivalence. When appointed to the MHRA in 1995 John took a concomitant five year Honorary Senior Lecturer post in Clinical Pharmacology at St Thomas’ Hospital.John’s previous appointments also include Senior Lecturer at the National Heart and Lung Institute, with Honorary Consultant status at the Brompton, Charing Cross and Chelsea & Westminster Hospitals, 1990-1994. This followed a Senior Registrar post in Clinical Pharmacology at the Royal Postgraduate Medical School from 1986-1990. He was a Member of the Editorial Board of Clinical Pharmacology & Therapeutics and Microvascular Research.He holds triple specialist accreditation in the UK in General Medicine, Clinical Pharmacology and Cardiology and is the author of over 100 publications in international journals on the physiology and pharmacology of the autonomic system and a book on the Endothelium.

FASEB Journals 1993;7:1394-1400; 1994;8:247-251; 1995:9:411-418;
Am J Physiol 1992;263:H1963-1966; 1993;265:H176-182; 1994;266:H1846-1853; 1998;275:H1388-1394;
Clinical Science 1983; 64:475-479; 1984; 66:79-85; 1984; 66:47-51.
Pharmacovigilance, in: The Law and Regulation of Medicines Oxf Uni Press 2008.
Lancet 2009;374:290. TIPS 2009;30:503-8.

John has widespread lecturing experience on a range of topics, including conferences organised by Informa, SMi, EU Association of Pharma Biotechnology, EU Center for Regulatory Affairs Freiburg, EU Generic Alliances’ Network, as well as MSc and BSc students at Oxford, Surrey and Kings College London. For a review of drug development please see “Drug Discovery: Lessons from Evolution” Br J Clinical Pharmacology 2011;71:497-503.

Dr Masamitsu Iino

Professor, Department of Pharmacology, Graduate School of Medicine, The University of Tokyo.

Masamitsu also serves as Second Vice President of IUPHAR and Secretary General of the 18^th World Congress of Basic and Clinical Pharmacology to be held in Kyoto in July 2018. He has been studying the mechanism of intracellular Ca²⁺ signaling, which is one of the most important biosignals regulating a vast array of cell functions. He discovered regenerativity of intracellular Ca²⁺ mobilization and showed that the mechanism is responsible for the generation of diverse spatiotemporal patterns of Ca²⁺ signals. He is now trying to identify new (patho)physiological cell functions that are regulated by Ca²⁺ signals in the central nervous system, using new methods based on his previous findings. His recent results clarified new Ca²⁺-dependent mechanisms in brain injury, which may serve as potential therapeutic targets.

Selected publications

Kanemaru, K., Kubota, J., Sekiya, H., Hirose, K., Okubo, Y. and Iino, M. Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury. Proc. Natl. Acad. Sci. U.S.A. 110, 11612-11617, 2013.
Kakizawa, S., Yamazawa, T., Chen, Y., Ito, A., Murayama, T., Oyamada, H., Kurebayashi, N., Sato, O., Watanabe, M., Mori, N., Oguchi, K., Sakurai, T., Takeshima, H., Saito, N. and Iino, M. Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function. EMBO J. 31, 417-428, 2012.
Okubo, Y., Sekiya, H., Namiki, S., Sakamoto, H., Iinuma, S., Yamasaki, M., Watanabe, M., Hirose, K. and Iino, M. Imaging extrasynaptic glutamate dynamics in the brain. Proc. Natl. Acad. Sci. U.S.A. 107, 6526-6531, 2010.
Furutani, K., Okubo, Y., Kakizawa, S. and Iino, M. Postsynaptic inositol 1,4,5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF. Proc. Natl. Acad. Sci. U.S.A. 103, 8528-8533, 2006.
Tomida, T., Hirose, K., Takizawa, A., Shibasaki, F., and Iino, M. NFAT functions as a working memory of Ca²⁺ signals in decoding Ca²⁺ oscillation. EMBO J. 22, 3825-3832, 2003.
Okubo, Y., Kakizawa, S., Hirose, K., and Iino, M. Visualization of IP₃ dynamics reveals a novel AMPA receptor-triggered IP₃ production pathway mediated by voltage-dependent Ca²⁺ influx in Purkinje cells. Neuron 32, 113-122, 2001.
Miyakawa, T., Mizushima, A., Hirose, K., Yamazawa, T., Bezprozvanny, I., Kurosaki, T. and Iino, M. Ca²⁺-sensor region of IP₃ receptor controls intracellular Ca²⁺ signalling. EMBO J. 20, 1674-1680, 2001.
Hirose, K., Kadowaki, S., Tanabe, M., Takeshima, H. and Iino, M. Spatio-temporal dynamics of Inositol 1,4,5-trisphosphate that underlies complex Ca²⁺ mobilization patterns. Science 284, 1527-1530, 1999.
Hirose, K. and Iino, M. Heterogeneity of channel density in inositol-1,4,5-trisphosphate-sensitive Ca²⁺ stores. Nature 372, 791-794, 1994.
Iino, M. and Endo, M. Calcium-dependent immediate feedback control of inositol 1,4,5-trisphosphate-induced Ca²⁺ release. Nature 360, 76-78, 1992.